Stem Cell Activation During Hair Regeneration
نویسندگان
چکیده
منابع مشابه
Cyclic dermal BMP signaling regulates stem cell activation during hair regeneration
In the age of stem cell engineering, it is critical to understand how stem cell activity is regulated during regeneration. Hairs are mini-organs that undergo cyclic regeneration throughout adult life,1 and are an important model for organ regeneration. Hair stem cells located in the follicle bulge2 are regulated by the surrounding micro-environment, or niche3. The activation of such stem cells ...
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Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF stem cells, leading to telogen-anagen transition (TAT) around the wound and de novo HF regeneration, mostly through TNF signalling. Both TNF knockout and overexpression attenuate HF neogenesis in wounds, suggesti...
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Introduction: During the last decade, advances in tissue engineering and stem cell-based tooth regeneration have provided realistic and attractive means of replacing lost or damaged teeth. The first adult stem cells isolated from dental tissues were dental pulp stem cells (DPSCs). When transplanted with hydroxyl apatite/tri calcium phosphate (HA/TCP) powder, they formed a dentin-like structure...
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Technologies such as hearing aids and cochlear implants do provide useful benefit to a large number of individuals with hearing loss, but they are incapable of truly “correcting” a hearing loss. In contrast to these, replacement of hair cells via stem cell therapies holds promise for a cure. Despite the discovery of stem/ progenitor cells in the mammalian cochlea, no regeneration of either dama...
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ژورنال
عنوان ژورنال: Microscopy and Microanalysis
سال: 2009
ISSN: 1431-9276,1435-8115
DOI: 10.1017/s1431927609097219